What Is Super TRIMIX? Is It Magic And What Can It Do For Me?
The inability to get and sustain an erection, affects nearly 18 million US men which is nearly half of all men aged 40 and up. Even more surprising, about 26% of men seeking treatment for the issue are under the age of 40. Many effective treatment options for ED (erectile dysfunction) exist, yet many men choose no treatment. Treatment costs, access, and medication side effects are all probable reasons for not treating ED. Oral ED medications can have significant unwanted side effects because they must be absorbed from the gut, processed by the liver and kidneys, and distributed throughout the body. Because Trimix and Super Trimix are locally injected, they have far fewer side effects.
HOW DOES SUPER TRIMIX WORK?
Super Trimix is a combination of three medications that all increase blood flow into the penis. Each medication works slightly differently, which allows them to have a synergistic effect when treating ED without the increase in side effects that would be expected when using multiple medications with the same mechanism of action.
Super Trimix is injected into the corpora cavernosa, two large sponge-like chambers inside the penis that fill with blood to generate an erection. Super Trimix’s formula combines three medications: papaverine, alprostadil, and phentolamine, which all increase blood flow into the corpora cavernosa.
PAPAVERINE
Papaverine relaxes smooth muscle lining blood vessels that supply blood flow to the penis and smooth muscle lining the corpora cavernosa. As a result, papaverine increases blood flow into the penis and decreases outflow from the penis. This traps blood in the shaft of the penis and generates an erection. Papaverine acts along several metabolic pathways to increase penile blood flow.
Papaverine has a higher risk of fibrosis and therefore is not used alone.5 It is used in conjunction with phentolamine and prostaglandin to improve ED treatment outcomes while minimizing side effects.
ALPROSTADIL
Alprostadil or prostaglandin E1 also relaxes smooth muscles. It can be injected into the corpora cavernosa or used by itself as an intraurethral pellet. Alprostadil is currently the only FDA-approved injectable medication for ED treatment.
Alprostadil’s most common side effects include: pain and blood in the urine. Alprostadil injections can cause priapism, but its rate of priapism is the lowest of the injectables, at 0.36% to 4%.
PHENTOLAMINE
Phentolamine is an alpha-adrenergic antagonist that blocks impulses from the sympathetic nervous system. The sympathetic nervous system constricts blood vessels in the penis, which reduces blood flow into the penis. Phentolamine relaxes the smooth muscle in blood vessels and the corpora cavernosa, allowing them to fill with blood. It is commonly used with papaverine.
WHAT STRENGTHS DOES SUPER TRIMIX COME IN?
Super Trimix is a sterile compounded medication that is filled by specialized compounding pharmacies. Since Super Trimix is custom formulated, it can be adjusted to better meet your needs.
Trimix Strength: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 1 mg/mL Prostaglandin E1 10 mcg/mL
Super Trimix strength: Papaverine HCl 30 mg/mL, Phentolamine Mesylate 2 mg/mL Prostaglandin E1 20 mcg/mL
HOW DO YOU INJECT SUPER TRIMIX?
Super Trimix is typically dispensed in a vial with insulin syringes that you use to give yourself the injection. Injected 5 to 10 minutes before sexual activity, erections generally last 30 to 60 minutes.
Following your healthcare provider’s instructions:
- Thaw your medication to room temperature
- Before filling the syringe, pull the plunger back, push the needle through the rubber stopper, and inject air into the vial
- Draw up your dosage from your Super Trimix vial
- Clean your penis with alcohol and let it dry
- Inject your medication into the side of the penis at the 10 o’clock and 2 o’clock positions, about mid-shaft
- Avoid injecting your medication into any visible blood vessel
- Rotate your injection site each time to help prevent scar tissue from developing
- After injecting your medication, apply pressure for 2 to 3 minutes
AND, IT IS TIME TO PLAY
Besides injectables, there are oral ED medications such as sildenafil, vardenafil, avanafil, and tadalafil. The most common name we have all heard of is Viagra. These medications are phosphodiesterase class 5 inhibitors (PDE5) that increase nitric oxide levels, which allow blood vessels and smooth muscle in the corpus cavernosa to dilate and fill with blood. Unlike Super Trimix, oral ED medications require sexual stimulation to work. Success rates with Trimix and Super Trimix approach 90% to 95%. Oral ED medications successfully treat 60% to 70% of men with moderate ED.
According to the American Urological Association, while oral ED medications are considered first-line, men should be offered all treatment options as long as they are not medically contraindicated. Trimix users are typically men who have tried oral ED medications, but many men are prescribed Trimix or Super Trimix as a first-line treatment due to the side effects associated with oral ED medications.
Now prick that prick and let’s play.
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